| Date | Opponenets | Comp | |||
| Sat 04/09/21 | Runcorn Linnets Yellows | Lge | H | 5 - 1 | Lewis Walsh 2, Jack Burke, Tom Evans, Lucas Rogers |
| Sat 11/09/21 | BRNESC | Lge | A | 2 - 2 | Lewis Walsh, Tom Evans |
| Fri 17/09/21 | Hyde United | FAYC | A | 0 - 5 | |
| Sat 25/09/21 | Mossley Hill Athletic | Lge | H | 4 - 0 | Tom Evans, Lewis Walsh Jack Burke 2 |
| Sat 09/10/21 | Mossley Hill | Lge | A | 3 - 3 | Jack Burke, Charlie Gresham 2 (2p) |
| Sat 23/10/21 | Vauxhall Motors | Lge | H | 2 - 2 | Dominic Earle, Lewis Walsh |
| Sat 30/10/21 | Maghull | Lge | A | 4 - 2 | Tom Evans, Mackenzie Hilton, Jack Burke 2 |
| Sat 13/11/21 | Maghull | LYC2 | H | 3 - 1 | MacKenzie Hilton, Gabriel McGinn 2 (2 pens) |
| Sat 20/11/21 | BRNESC | Lge | H | 2 - 3 | Ramon Smith 2 |
| Sat 27/11/21 | Victoria Colts | Lge | H | 2 - 0 | Ramon Smith, McKenzie Hilton |
| Sat 04/12/21 | Mossley Hill Athletic | Lge | A | 6 - 4 | Billy Eaglestone, Tom Evans, Jack Burke, Lucas Rogers, Jamie Kilcourse, Lewis Walsh |
| Sat 18/12/21 | Maghull | Lge | H | 9 - 0 | Jack Burke 3, Tom Evans, MacKenzie Hilton, Adam Idowu, Lewis Walsh 2, Gabriel McGinn |
| Sat 15/01/22 | Inny Boys | LYCqf | A | 3 - 3 | Lucas Rogers, Jack Burke (lost on pens 5 - 6) |
| Sat 29/01/22 | Runcorn Linnets | Plate | A | 6 - 0 | Jordan Mothe 3, Jack Burke, Charlie Gresham, Billy Eaglestone |
| Sat 12/02/22 | City of Liverpool | Lge | H | 4 - 1 | Jordan Monthe, Jack Burke, Jamie Kilcourse, MacKenzie Hilton |
| Sat 26/02/22 | Mossley Hill | Plate | H | 3 - 2 | After Extra Time (ft 1 - 1) Charlie Hacking, Tom Evans, Gabriel McGinn (pen) |
| Sat 26/03/22 | Mossley Hill Athletic | Plate | H | 5 - 5 |
After Extra Time (FT 3 - 3) South won on pens 8 -7 Charlie Gresham, Lucas Rogers, Tom Evans 2 & McKenzie Hilton |
| Sat 23/04/22 | City of Liverpool Partisans | Lge | A | 3 - 2 | Own Goal, Tom Evans, Joe Fitzpatrick |
| Tue 26/04/22 | Vauxhall Motors | Plate | A | 1 - 4 | Jack Burke |
| Sat 30/04/22 | Mossley Hill | Lge | H | 2 - 2 | McKenzie Hilton, Lewis Walsh |
| Tue 03/05/22 | City of Liverpool | Lge | A | AW | |
| Sat 07/05/22 | Victoria Colts | Lge | A | 0 - 3 | |
| Mon 09/05/22 | Poulton Victoria | Lge | A | HW | |
| Fri 13/05/22 | Vauxhall Motors | Lge | A | HW | |
| Mon 16/05/22 | Runcorn Linnets | Lge | A | HW | |
| Wed 18/05/22 | Poulton Victoria | Lge | H | AW | |
| Sat 21/05/22 | City of Liverpool Partisans | Lge | H | AW |